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March 25, 2026BiomaterialsOpen Access

Mechanobiological engineering strategies for oral and maxillofacial tissue regeneration

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Authors

JPJae Hee ParkVSVarsha SagarKLKam W. Leong

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Overview

This review explores mechanobiological strategies that enhance tissue regeneration, suggesting innovative therapies for oral and maxillofacial tissues.

Key Points

  • This review aims to reframe oral and maxillofacial tissue regeneration via a mechanobiological approach, emphasizing the role of mechanical forces.
  • Summarizes advancements in intrinsic and extrinsic mechanobiological strategies.
  • Describes the use of biomaterials with specific mechanical properties to enhance tissue regeneration.
  • Discusses engineered platforms for applying mechanical stimuli to activate healing processes.
  • Identifies barriers to clinical application and opportunities for future research.
  • Mechanobiological design can recreate tissue-specific mechanical environments using advanced biomaterials.
  • Extrinsic mechanotherapy methods, like ultrasound and electrical stimulation, show promise in activating regeneration.
  • The review highlights the need for standardization in mechanical dosing and testing methodologies.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69c37b33b34aaaeb1a67d5a8https://doi.org/10.1016/j.biomaterials.2026.124158
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Also Consider

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  1. 1Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications2026
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  4. 4Biomaterials for Oral and Maxillofacial Regeneration: Advances, Challenges, and Future Directions2025
  5. 5Regenerative Dentistry and Dental Tissue Engineering: Contemporary Strategies, Biomaterials, and Clinical Applications2026