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April 5, 2026Cancer Research

Personalized cfDNA Fragmentation Dynamics in Early-Stage NSCLC

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Authors

JWJonathan C. M. WanWLWing K. LiuJBJames R. M. Black

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Overview

Longitudinal analysis of cfDNA fragmentation dynamics reveals treatment effects in early-stage NSCLC, suggesting implications for monitoring disease status.

Key Points

  • This research focuses on the dynamics of cfDNA and ctDNA fragmentation in early-stage NSCLC during treatment and follow-up.
  • Characterized cfDNA fragmentation using 1,069 longitudinal plasma samples from 197 individuals.
  • Applied anchored multiplex PCR and targeted sequencing for analysis.
  • Developed a computational pipeline to extract fragment size distributions and end-motif features.
  • Distinct cfDNA fragmentation patterns were observed over various clinical timepoints.
  • Mutant cfDNA fragments were found to be shorter than non-mutant fragments.
  • Alterations in fragmentation patterns were linked to treatment effects, with a transient release of non-tumor cfDNA post-surgery.

Cite This Study

Wan et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcd4a79560c99a0a27eahttps://doi.org/10.1158/1538-7445.am2026-1128
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