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April 10, 2014PLoS Computational Biology7,084 citationsOpen Access

BEAST 2: A Software Platform for Bayesian Evolutionary Analysis

RBRemco BouckaertJHJoseph HeledDKDenise Kühnert

Key Points

  • To introduce a redesigned software platform, BEAST 2, for Bayesian evolutionary analysis that addresses limitations of BEAST 1.
  • Developed a new package management system for easy extension of functionality.
  • Enabled reading/writing of MCMC chain states to/from disk for better sharing and checkpointing.
  • Integrated user interface (BEAUti 2) with a consistent XML file format for improved usability.
  • Introduced new models for birth-death-sampling tree priors, phylodynamics, and model averaging.
  • Facilitated multi-processor support for high-end computing by improved state handling.
  • Enhanced user interface integration allows seamless addition of new functionality through XML.

Abstract

We present a new open source, extensible and flexible software platform for Bayesian evolutionary analysis called BEAST 2. This software platform is a re-design of the popular BEAST 1 platform to correct structural deficiencies that became evident as the BEAST 1 software evolved. Key among those deficiencies was the lack of post-deployment extensibility. BEAST 2 now has a fully developed package management system that allows third party developers to write additional functionality that can be directly installed to the BEAST 2 analysis platform via a package manager without requiring a new software release of the platform. This package architecture is showcased with a number of recently published new models encompassing birth-death-sampling tree priors, phylodynamics and model averaging for substitution models and site partitioning. A second major improvement is the ability to read/write the entire state of the MCMC chain to/from disk allowing it to be easily shared between multiple instances of the BEAST software. This facilitates checkpointing and better support for multi-processor and high-end computing extensions. Finally, the functionality in new packages can be easily added to the user interface (BEAUti 2) by a simple XML template-based mechanism because BEAST 2 has been re-designed to provide greater integration between the analysis engine and the user interface so that, for example BEAST and BEAUti use exactly the same XML file format.

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Cite This Study

Bouckaert et al. (2014) studied this question.

synapsesocial.com/papers/69d7b9ec05ee2ba81dbed845https://doi.org/10.1371/journal.pcbi.1003537
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