What question did this study set out to answer?

This research aims to investigate how methyl-β-cyclodextrin (MβCD) can improve the effectiveness of paclitaxel (PTX) in treating breast cancer.

April 10, 2026

Methyl-β-Cyclodextrin Enhances the Chemotherapeutic Efficacy ofPaclitaxel in Breast Cancer Cells

Key Points

This research aims to investigate how methyl-β-cyclodextrin (MβCD) can improve the effectiveness of paclitaxel (PTX) in treating breast cancer.
Utilized sequential therapy with methyl-β-cyclodextrin and PTX-loaded liposomes (PTX-LPs)
Examined the effects on drug efflux
Assessed the integrity of lipid rafts in breast cancer cells
MβCD significantly enhances the efficacy of PTX-LPs in breast cancer cells
Inhibition of drug efflux was observed via lipid raft disruption
Suggests potential for overcoming chemoresistance in treatment

Abstract

Sequential therapy with MβCD and PTX-LPs enhances the chemotherapeutic efficacy of PTX-LPs in breast cancer. This effect is mediated by the inhibition of drug efflux through the disruption of lipid raft integrity. This strategy provides a novel approach to overcoming chemoresistance.

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Cite this study

Jin et al. (Mon,) studied this question.

www.synapsesocial.com/papers/69d893626c1944d70ce04722 — DOI: https://doi.org/10.2174/0115680096430730260120060026

Authors

Haili Jin

Liping Zhou

Tianzhen Lin

Journals

Current Cancer Drug Targets

Actions

Institutions

Zhejiang University

Wenzhou Medical University

First Affiliated Hospital Zhejiang University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Methyl-β-Cyclodextrin Enhances the Chemotherapeutic Efficacy ofPaclitaxel in Breast Cancer Cells

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion