What question did this study set out to answer?

This research aims to investigate how methyl-β-cyclodextrin (MβCD) can improve the effectiveness of paclitaxel (PTX) in treating breast cancer.

April 10, 2026

Methyl-β-Cyclodextrin Enhances the Chemotherapeutic Efficacy ofPaclitaxel in Breast Cancer Cells

Key Points

This research aims to investigate how methyl-β-cyclodextrin (MβCD) can improve the effectiveness of paclitaxel (PTX) in treating breast cancer.
Utilized sequential therapy with methyl-β-cyclodextrin and PTX-loaded liposomes (PTX-LPs)
Examined the effects on drug efflux
Assessed the integrity of lipid rafts in breast cancer cells
MβCD significantly enhances the efficacy of PTX-LPs in breast cancer cells
Inhibition of drug efflux was observed via lipid raft disruption
Suggests potential for overcoming chemoresistance in treatment

Abstract

Sequential therapy with MβCD and PTX-LPs enhances the chemotherapeutic efficacy of PTX-LPs in breast cancer. This effect is mediated by the inhibition of drug efflux through the disruption of lipid raft integrity. This strategy provides a novel approach to overcoming chemoresistance.

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Discussion

Authors

Haili Jin

Liping Zhou

Tianzhen Lin

Journals

Current Cancer Drug Targets

Actions

Institutions

Zhejiang University

Wenzhou Medical University

First Affiliated Hospital Zhejiang University

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Methyl-β-Cyclodextrin Enhances the Chemotherapeutic Efficacy ofPaclitaxel in Breast Cancer Cells

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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