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April 16, 2026Journal of Bone and Mineral Research2 citations

Weekend Warrior Physical Activity Pattern, Metabolomic Profiles, and Risk of Osteoporosis and Fracture

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HHHuan HuangJLJiong LiuPLPeixuan Li

Key Points

  • This research investigates how the weekend warrior physical activity pattern affects the risk of osteoporosis and fractures, alongside identifying related metabolites.
  • Included 14,069 UK Biobank participants with accelerometer and metabolomic data.
  • Examined physical activity patterns using Cox proportional hazards models.
  • Identified metabolites linked to activity patterns using elastic net regression.
  • Conducted analyses based on polygenic risk scores for osteoporosis and fracture.
  • Weekend warrior pattern was linked to reduced risks of osteoporosis (HR: 0.59) and fracture (HR: 0.77).
  • Identified 51 metabolites for the weekend warrior pattern and 62 for regular activity.
  • Each SD increase in metabolomic signature corresponded to 27% lower osteoporosis risk (HR: 0.73) and 12% lower fracture risk (HR: 0.88).
  • Associations were not notably influenced by genetic susceptibility to osteoporosis or fracture.

Abstract

Abstract Background 95% CI: 0.44-0.79) and fracture (HR: 0.77; 95% CI: 0.63-0.95). Using elastic net regression, we identified 51 metabolites characterizing the weekend warrior pattern and 62 metabolites representing regular physical activity. Each standard deviation (SD) increase in the weekend warrior-related metabolomic signature corresponded to a 27% lower risk of osteoporosis (HR: 0.73; 95% CI: 0.62-0.85) and a 12% lower risk of fracture (HR: 0.88; 95% CI: 0.79-0.99). These associations were not significantly modified by genetic susceptibility to osteoporosis (P = 0.429) or fracture (P = 0.221). Conclusions The weekend warrior pattern was associated with lower risks of osteoporosis and fracture. We further identified distinct metabolomic signature characterizing this pattern, providing potential mechanistic insights into its protective effects.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69e07cfa2f7e8953b7cbe10dhttps://doi.org/10.1093/jbmr/zjag067
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