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April 27, 2026Scientific ReportsOpen Access

Solvent-free and green synthesis of fused pyrimidine derivatives catalyzed by pillar5arene-based Lewis acid ionic liquid

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Authors

SRSoheila RastegarIMIraj Mohammadpoor‐BaltorkSASaeid Asghari

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Overview

Randomized trial demonstrates efficient synthesis of fused pyrimidine derivatives, highlighting green chemistry implications.

Key Points

  • The aim is to develop a sustainable method for synthesizing 7,9-diaryl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one derivatives using a novel catalyst.
  • Utilized a one-pot, three-component reaction of 4-aminocoumarin, aromatic aldehydes, and 1-aryl-2-thiocyanatoethan-1-ones.
  • Employed a pillar[5]arene-based Lewis acid ionic liquid as the catalyst under solvent-free conditions.
  • Assessed catalyst reusability over six cycles without significant activity loss.
  • Achieved yields of 70–95% for various DCTP derivatives, reflecting catalyst efficiency.
  • Demonstrated potential for selective synthesis of mono-DCTP derivatives from dialdehydes.
  • Obtained high turnover numbers (TON ~ 52–70), emphasizing aligned efficiency with green chemistry principles.

Cite This Study

Rastegar et al. (2026) studied this question.

synapsesocial.com/papers/69eefd64fede9185760d41e3https://doi.org/10.1038/s41598-026-48554-8
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  5. 5Paired Electrolysis Synthesis of 5,7‐Disubstituted Thiazolo[5,4‐d]pyrimidine‐4,6‐diones2026