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April 28, 2026Frontiers in Aging NeuroscienceOpen Access

Ketogenic metabolic therapy: low-carbohydrate interventions as novel neuroprotective strategies for cognitive dysfunction in diabetes

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Authors

YXYing XunWZWenqing Zeng

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Overview

Narrative review evaluates low-carbohydrate diets' efficacy for cognitive benefits in diabetes, highlighting future research needs.

Key Points

  • The review aims to assess the efficacy of low-carbohydrate ketogenic diets for cognitive dysfunction related to diabetes.
  • Critically evaluates preclinical and clinical evidence on LCKDs for cognitive health.
  • Focuses on mechanisms such as mitochondrial bioenergetics and neuro-inflammation.
  • Identifies limitations in current literature and suggests frameworks for future research.
  • LCKDs potentially improve glycemic control and metabolic health.
  • Evidence indicates cognitive benefits through enhanced bioenergetics and reduced inflammation.
  • Key limitations highlighted warrant further investigation to support findings.

Cite This Study

Xun et al. (2026) studied this question.

synapsesocial.com/papers/69f04d9f727298f751e71f1chttps://doi.org/10.3389/fnagi.2026.1777834
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ketogenic Diet and Brain Health: Cerebrovascular Mechanisms, Neuroprotection, and Translational Implications2026 · 2 citations
  2. 2Ketogenic diet in the management of disease.2025
  3. 3Ketogenic Metabolism in Neurodegenerative Diseases: Mechanisms of Action and Therapeutic Potential2025
  4. 4Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial2019 · 73 citations
  5. 5Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer's disease mouse models2024