(MRSA) bacteremia. Both children initially presented with nonspecific limb pain, fever, and markedly elevated inflammatory markers, with early imaging proving nondiagnostic. Each subsequently developed venous thrombosis and septic emboli prior to confirmation of osteomyelitis, reflecting an aggressive clinical pattern. MRI later revealed multifocal bone involvement with subperiosteal abscesses requiring surgical drainage. Management required prolonged targeted intravenous antibiotics, anticoagulation, and coordinated multidisciplinary care. These cases highlight the importance of early suspicion for musculoskeletal infection in febrile children with persistent limb pain and systemic MRSA infection. Early MRI and prompt recognition of thromboembolic complications are essential for improving outcomes.
Abdallah et al. (2026) studied this question.