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May 6, 20260 citationsOpen Access

Characteristic Clinical Features of Melanoma in Patients With Excised Skin Lesions.

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OMOLIWIA MAJEWSKAPKPiotr KuligPBPaweł Brzewski

Key Points

  • This research aims to evaluate the melanoma risk in patients with excised skin lesions by analyzing their clinical features.
  • Collected data from 126 excised skin lesions between December 2021 and April 2025.
  • Analyzed clinical features of 109 benign skin lesions, 10 non-nodular melanomas, and 7 nodular melanomas using ABCDE criteria, ABCDE-EFG method, and 7-point checklist.
  • Conducted multivariate analysis to identify significant clinical features distinguishing melanomas from benign lesions.
  • Significant clinical features such as color variegation and changes within six months were found in NNMs and NMs compared to BSLs (p=0.027).
  • For nodular melanomas, no unique clinical features were identified compared to benign skin lesions in the multivariate analysis.

Abstract

Background/Aim: The aim of this study was to assess the risk of melanoma in patients with excised skin lesions (ESLs) considering their clinical features. Patients and Methods: A total of 126 cases of ESLs were collected between December 2021 and April 2025. The clinical features of 109 benign skin lesions (BSLs), 10 non-nodular melanomas (NNMs), and seven nodular melanomas (NMs) were analyzed according to the ABCDE criteria, the ABCDE-EFG method, and the 7-point checklist (7-PCL) scale. Results: =0.027) were also found to be significant in differentiating for both NNMs and NMs compared to BSLs. However, in multivariate analysis, for NMs alone, no clinical features were significantly more frequent compared to BSLs. Conclusion: , color variegation and evolution in size, shape or color within six months, but not for NMs cases alone in the Firth's penalized logistic regression.

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Cite This Study

MAJEWSKA et al. (2026) studied this question.

synapsesocial.com/papers/69fada7f03f892aec9b1e43fhttps://doi.org/10.21873/cdp.10540
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