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May 6, 2026International Journal of Biomedical ImagingOpen Access

Personalized PET Imaging in Gastric Cancer: An Umbrella Review of Meta‐Analyses to Guide Radiopharmaceutical Selection and Clinical Indication

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Authors

AAAiganym AmrenovaASAlma ShukirbekovaSASholpan Akhelova

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Overview

Umbrella review synthesizes meta-analytic evidence on PET imaging in gastric cancer, suggesting personalized tracer selection.

Key Points

  • The aim is to synthesize evidence on PET imaging performance in gastric cancer, focusing on specific radiopharmaceuticals and their clinical indications.
  • Conducted an umbrella review following PRISMA 2020 guidelines.
  • Searched PubMed, Scopus, and Web of Science for relevant systematic reviews and meta-analyses.
  • Evaluated outcomes including diagnostic accuracy, staging, and methodological quality.
  • Ga-FAPI PET demonstrated higher pooled sensitivity than FDG for detecting primary tumors, nodal disease, and recurrence.
  • Certainty of evidence for Ga-FAPI ranges from low to moderate due to study heterogeneity.
  • FDG PET remains important for prognostic stratification in specific recurrence scenarios.

Cite This Study

Amrenova et al. (2026) studied this question.

synapsesocial.com/papers/69fada7f03f892aec9b1e446https://doi.org/10.1155/ijbi/3450212
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Personalized PET imaging in gastric cancer: An umbrella review of meta-analyses to guide radiopharmaceutical selection and clinical indication2026
  2. 2Role of Gallium 68 fibroblast activation protein inhibitor PET/CT in the initial evaluation of gastric adenocarcinoma: a single-institution retrospective study2025
  3. 3Diagnostic Efficacy of FAPI-PET/CT Versus [18F]FDG-PET/CT in Upper-Abdominal Malignancies: A Systematic Review and Meta-Analysis2026 · 2 citations
  4. 4Comparison of 68Ga-FAPI PET/CT and 18F-FDG PET/CT in Gastric Cancer: Impact on Metastatic Detection and Stage Migration2026
  5. 5Role of 68 Ga FAPI PET-CT Versus 18 F-FDG PET-CT in the Diagnostic Evaluation of Poorly Cohesive Gastric Carcinomas2026