Complete tumor resection and vascular reconstruction for angiomatoid fibrous histiocytoma with direct vascular invasion resulted in no local recurrence or distant metastasis at 12 months.
Case Report (n=1)
No
Does complete tumor resection and vascular reconstruction prevent recurrence in a patient with Angiomatoid fibrous histiocytoma involving the superficial femoral vein?
This first reported case of AFH with direct vascular invasion suggests that complete surgical resection is effective and vascular involvement may not indicate a malignant phenotype.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm predominantly occurring in the extremities of children and young adults. This report presents an 8-year-old girl with AFH involving the superficial femoral vein. The patient was successfully managed with complete tumor resection and vascular reconstruction. No local recurrence or distant metastasis was detected during the 12-month follow-up. To our knowledge, this is the first reported case of AFH with direct vascular invasion. Our findings suggest that complete surgical resection remains the primary treatment, and vascular involvement may not necessarily indicate a malignant phenotype in AFH.
Jing et al. (2026) conducted a case report in Angiomatoid fibrous histiocytoma (n=1). Complete tumor resection and vascular reconstruction was evaluated on Local recurrence or distant metastasis. Complete tumor resection and vascular reconstruction for angiomatoid fibrous histiocytoma with direct vascular invasion resulted in no local recurrence or distant metastasis at 12 months.