Cross-sectional analysis reveals monocyte depletion correlates with disease progression in AIDS patients with Talaromycosis Marneffei, suggesting immunotherapy targets.
Key Points
The research aims to analyze inflammatory activation and monocyte dynamics in AIDS patients with Talaromycosis Marneffei.
Conducted a cross-sectional study comparing AIDS/TSM with AIDS/PCP, AIDS/TB, and healthy controls.
Analyzed peripheral blood mononuclear cell ratios and absolute values using correlation analyses.
Utilized flow cytometry and transcriptome sequencing to characterize monocytes in AIDS/TSM patients.
Significant reduction in monocyte numbers and proportions in TSM patients.
Reduction correlated with disease progression indicators (PLT, ALT, AST, ALB).