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May 7, 2026Cardiovascular & Hematological Agents in Medicinal Chemistry

Administration of Aspirin and Aqueous Leaf Extract of Terminalia Catappa Reduces Leukocytosis with Risk of Developing Thrombocytosis in DiabeticWistar Rats

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Authors

EBEzekiel Etim BenJBJustin Atiang BeshelAAAsuquo E. Asuquo

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Overview

Administration of aspirin and Terminalia catappa extract lowers leukocytosis in diabetic rats, indicating potential for inflammation reduction.

Key Points

  • To evaluate the effects of aspirin and Terminalia catappa extract on leukocyte count and platelet indices in diabetic rats.
  • Male Wistar rats were divided into seven groups including control and diabetic groups.
  • Diabetes was induced with alloxan at 150 mg/kg.
  • Groups received either distilled water, aspirin (30 mg/kg), meloxicam (2 mg/kg), or Terminalia catappa extract (130 mg/kg) for 14 days.
  • Total WBC count and inflammation markers were significantly elevated in diabetic rats.
  • Aspirin and Terminalia catappa extract effectively reduced WBC count and inflammation markers.
  • Platelet indices increased in groups treated with extract and aspirin compared to control.

Cite This Study

Ben et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2fe2https://doi.org/10.2174/0118715257457865260428052651
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