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May 7, 2026AntioxidantsOpen Access

Protective Effects of Fisetin Against Oxidative Stress in Human Sperm: Implications for Cryopreservation

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Authors

SASara Al-MashharawiRDRahaf DabeZAZina Al-Alami

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Overview

Fisetin demonstrates improved sperm viability and motility under oxidative stress, indicating its potential in cryopreservation.

Key Points

  • This research evaluates the protective effects of fisetin against oxidative stress in human sperm, particularly during cryopreservation.
  • Fisetin was tested at concentrations of 15 and 30 µM on normozoospermic semen samples.
  • Sperm samples were assessed after freezing in liquid nitrogen or exposure to H2O2 to induce oxidative stress.
  • Sperm motility, viability, mitochondrial membrane potential, metabolic activity, and other parameters were measured.
  • Fisetin significantly improved sperm motility and viability under oxidative stress conditions.
  • It reduced reactive oxygen species and lipid peroxidation, improving mitochondrial and metabolic activity.
  • The 30 µM concentration of fisetin showed greater effectiveness in protecting sperm.

Cite This Study

Al-Mashharawi et al. (2026) studied this question.

synapsesocial.com/papers/69fbefa3164b5133a91a3abchttps://doi.org/10.3390/antiox15050583
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