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May 7, 20260 citations

Kininogen 1/Bradykinin Receptor B2 System in Vancomycin Nephrotoxicity and Absintin Targeting

The Kininogen 1/bradykinin receptor B2 system serves as a key molecular response of vancomycin-induced nephrotoxicity and may be a potential target of absinthin.

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Authors

JLJiangying LongSZShaoshan ZhouCLC Li

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Overview

Experimental model reveals absinthin may reduce nephrotoxicity and enhance therapeutic strategy targeting bradykinin receptor B2.

Key Points

  • To explore the molecular response to vancomycin-induced nephrotoxicity and identify potential gene targets with absinthin's effect.
  • Used Gene Expression Omnibus datasets to filter for differentially expressed genes.
  • Established a mouse model for nephrotoxicity via vancomycin injections.
  • Assessed renal injury using biomarkers like serum creatinine and blood urea nitrogen.
  • Malondialdehyde levels significantly increased in vancomycin-treated mice.
  • Absinthin reduced podocyte apoptosis in vancomycin-induced nephrotoxicity.
  • Blood urea nitrogen levels decreased with absinthin treatment.

Cite This Study

Long et al. (2026) studied this question.

synapsesocial.com/papers/69fbefc0164b5133a91a3cd9https://doi.org/10.14670/hh-25-085
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