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May 7, 2026Journal of Antimicrobial Chemotherapy

A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 1: setting the stage

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Authors

SHSarah HendrickxKIKayhan IlbeigiETEli S J Thoré

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Overview

This roadmap presents strategies for drug development in kinetoplastid diseases, highlighting funding and preclinical R&D implications.

Key Points

  • To introduce a structured roadmap to facilitate drug development in diseases caused by kinetoplastids.
  • Developing a pragmatic framework for drug discovery
  • Identifying preclinical R&D stages including hit finding and lead definition
  • Outlining laboratory experimental models and endpoints
  • Established a roadmap that reduces risk in drug development
  • Highlighted the importance of funding in the drug discovery process
  • Presented proof-of-concepts applicable to multiple microbial diseases

Cite This Study

Hendrickx et al. (2026) studied this question.

synapsesocial.com/papers/69fbefd5164b5133a91a3daahttps://doi.org/10.1093/jac/dkag109
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