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May 7, 2026Journal of Oral Biology and Craniofacial ResearchOpen Access

Synergistic HA–tooth graft composite promotes rapid alveolar bone healing via IL-6 suppression and OCN enhancement

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Authors

DIDwi Wahyu IndrawatiESErnie Maduratna SetiawatieRRRetno Pudji Rahayu

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Overview

Randomized trial evaluates HA-BTG's effect on bone healing in rats, suggesting its potential in regenerative therapy.

Key Points

  • This research investigates the impact of a hyaluronic acid-bovine tooth graft composite on alveolar bone healing and inflammation reduction.
  • Thirty-six male Wistar rats were divided into three groups: control, HA, and HA + BTG.
  • Following tooth extraction and periodontitis induction, IL-6 and OCN were assessed via immunohistochemistry.
  • Tissue samples collected on days 14 and 21 were analyzed for woven bone formation using H&E staining.
  • HA + BTG group showed a significant reduction in IL-6 expression compared to control (p < 0.05).
  • There was a significant increase in OCN expression in the HA + BTG group, indicating enhanced osteoblastic activity.
  • Woven bone area was significantly greater in the HA + BTG group compared to control, reflecting improved bone regeneration.

Cite This Study

Indrawati et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c718b49bacb8b3480achttps://doi.org/10.1016/j.jobcr.2026.101451
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