Why the study?
Breakthrough strokes occur in patients taking antiplatelets or anticoagulation, with high recurrence rates and multiple potential causes; this audit aimed to determine their incidence and investigate possible causes.
What is the incidence and what are the causes of breakthrough strokes in patients admitted with acute ischaemic stroke?
Population
326 patients admitted to a tertiary NHS hospital with acute ischaemic stroke confirmed on CT/MRI
Design
Retrospective audit
Key result
Breakthrough strokes occurred in 47.85% of patients admitted with acute ischaemic stroke, with hypertension being the most common risk factor across all medication groups.
Authors
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Urges caution with single antiplatelet therapy for secondary stroke prevention; leaves open superior strategies pending RCTs.
Observational (n=326)
No
What is the incidence and what are the causes of breakthrough strokes in patients admitted with acute ischaemic stroke?
Breakthrough strokes occurred in nearly half of patients admitted with acute ischemic stroke, highlighting the need to address uncontrolled risk factors like hypertension and screen for atrial fibrillation.
Maged et al. (2026) conducted an observational in Acute ischaemic stroke (n=326). Antiplatelets or anticoagulation was evaluated on Incidence of breakthrough strokes. Breakthrough strokes occurred in 47.85% of patients admitted with acute ischaemic stroke, with hypertension being the most common risk factor across all medication groups.