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May 8, 2026Organic Letters0 citations

Direct Deaminative C(sp 3 )–N Cross-Coupling via Copper Catalysis

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YYYuqi YangXPXidong PangYWYi Wei

Key Points

  • The aim is to develop a new method for directly transforming aliphatic amines into reactive alkyl radicals using copper catalysis.
  • Utilized copper catalysis to facilitate the deaminative cross-coupling process.
  • Conducted reactions under mild conditions.
  • Explored a broad substrate scope for diverse aliphatic amines.
  • Successfully generated reactive alkyl radicals.
  • Achieved the transformation of various aliphatic amines.
  • Demonstrated a practical application for radical reactions in organic synthesis.

Abstract

generate reactive alkyl radicals. This protocol proceeds under mild reaction conditions and exhibits a broad substrate scope. The success of this reaction provides a novel and practical approach for the direct transformation of aliphatic amines in radical reactions.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf06626https://doi.org/10.1021/acs.orglett.6c01556
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