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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1390 Less Is More: The Notch3-SVD Staging System Versus Serum Neurofilament Light as a Predictor for Disease Progression in Cadasil

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Authors

GGGido GravesteijnRHRemco J. HackMCMinne N. Cerfontaine

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Overview

Randomized trial examines disease prediction in CADASIL, highlighting the NOTCH3-SVD staging system's superiority over serum neurofilament light.

Key Points

  • To evaluate the predictive value of the NOTCH3-SVD staging system compared to serum neurofilament light in CADASIL disease progression.
  • Analyzed serum neurofilament light levels in 55 CADASIL patients at baseline and 2-year follow-up.
  • Used generalized linear models to assess associations with ischemic stroke, lacunes, and microbleeds across different models.
  • Accounted for age and NOTCH3-SVD stage when analyzing predictive factors.
  • Baseline sNfL predicted 2-year incident lacunes and microbleeds but not stroke (model 1).
  • Predictive effect of sNfL decreased when age was included (model 2).
  • NOTCH3-SVD stage was predictive for incident stroke, lacunes, and microbleeds in the combined model (model 3).

Cite This Study

Gravesteijn et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf066c0https://doi.org/10.1093/esj/aakag023.095
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