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February 8, 2017Science Translational Medicine581 citations

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin

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JZJin ZhengVNVu H. NguyenSJShengnan Jiang

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Abstract

resulted in phenotypic and functional activation of intratumoral macrophages with M1 phenotypes and a reciprocal reduction in M2-like suppressive activities. Together, these findings provide evidence that nonvirulent tumor-targeting bacteria releasing multiple TLR ligands can be used as cancer immunotherapeutics.

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Zheng et al. (2017) studied this question.

synapsesocial.com/papers/6a032911bc3ffe278e654df5https://doi.org/10.1126/scitranslmed.aak9537
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