Lower eGFR was significantly associated with higher left atrial low-voltage area burden in elderly patients with paroxysmal atrial fibrillation (76.4 vs 86.6 for LVA >15% vs ≤5%; p=0.003).
Observational (n=435)
Is lower eGFR associated with higher left atrial low-voltage area burden in elderly patients with paroxysmal atrial fibrillation?
Lower eGFR is associated with a higher left atrial low-voltage area burden in elderly patients with paroxysmal atrial fibrillation, suggesting renal function may help predict LVA before ablation.
Absolute Event Rate: 76.4% vs 86.6%
p-value: p=0.003
ABSTRACT Background Circumferential pulmonary vein isolation (CPVI) plus left atrial low‐voltage areas (LVA) modification is a useful method to treat paroxysmal atrial fibrillation (PAF); however, it is hard to predict LVA burden before the procedure. The existence of chronic kidney disease (CKD) increases the prevalence of left atrial LVA. In this study, we explored the relationship between renal function and the LVA burden in elderly patients with PAF. Methods We retrospectively analyzed the 435 elderly patients with PAF who underwent ablation. Based on the LVA burden measured during the procedure, the patients were divided into four groups: Group 1 (LVA burden ≤ 5%, n = 356), Group 2 (LVA burden 5%–10%, n = 39), Group 3 (LVA burden 10%–15%, n = 16), and Group 4 (LVA burden > 15%, n = 24). Results Increasing LVA burden was associated with a progressive decline in eGFR. A significant difference was observed between Group 1 and Group 4 (86.6 ± 12.9 vs. 76.4 ± 17.7, p = 0.003). eGFR was identified to be a predictor for LVA burden > 10%, with the optimal cut‐off value for GFR being 75.7 mL/min/1.73 m 2 , having a sensitivity of 54.2% and specificity of 80.4%. Conclusions A lower eGFR is associated with higher LVA burden in elderly patients with PAF.
Shaoxiong et al. (2025) conducted an observational in Paroxysmal Atrial Fibrillation (n=435). Renal function (eGFR) was evaluated on eGFR in patients with LVA burden >15% vs ≤5% (p=0.003). Lower eGFR was significantly associated with higher left atrial low-voltage area burden in elderly patients with paroxysmal atrial fibrillation (76.4 vs 86.6 for LVA >15% vs ≤5%; p=0.003).