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September 5, 2025British Journal of HaematologyOpen Access

NEAT1 lncRNA overexpression results in short‐term progression and poor treatment outcome in childhood B‐ALL

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Authors

MXMarieta XagorariAMAntonios MarmarinosDDDimitrios Doganis

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Overview

Analysis reveals NEAT1 lncRNA is a significant predictor of progression and treatment outcomes in childhood B-ALL.

Key Points

  • Children with NEAT1 overexpression in chB-ALL showed a significantly higher risk of disease progression.
  • Survival analysis indicated patients with NEAT1 overexpression had worse outcomes with a hazard ratio of 5.832.
  • Bootstrap analysis was utilized for internal validation, demonstrating the predictive capability of NEAT1 for chB-ALL patients.
  • NEAT1-based models improved risk stratification over conventional markers, suggesting enhanced clinical benefit.

Cite This Study

Xagorari et al. (2025) studied this question.

synapsesocial.com/papers/68bb49d26d6d5674bcd00108https://doi.org/10.1111/bjh.70127
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