This biosensor demonstrates enhanced sensitivity and antifouling capability for accurate detection of Alzheimer's biomarkers, highlighting its potential for diagnostic use.
Key Points
The biosensor achieved a low limit of detection of 0.1 fg/mL for Alzheimer's biomarker P-tau181.
Diagnostic accuracy reached an impressive 100% across 25 serum samples, indicating reliable performance.
Using an amyloid-like nanofilm improved antifouling properties, reducing nonspecific responses to less than 5%.
Weakening of Debye shielding through the nanofilm's porous structure enabled effective biomarker detection even in high ionic strength solutions.