Solid dispersions have garnered significant attention for their ability to enhance the dissolution rate and bioavailability of hydrophobic drugs. This comprehensive review delves into the various preparation techniques and recent technological advancements in solid dispersion technology. The article explores the different types of solid dispersions, classified based on their molecular arrangement, and discusses key practical considerations for their preparation. These include the selection of suitable carriers and methods for physicochemical characterization. This review also highlights the various carriers employed in solid dispersion preparation, their corresponding outcomes, and the underlying mechanisms driving solubility enhancement. By examining the role of carriers such as polymers, surfactants, and other excipients, we can gain a deeper understanding of how solid dispersions improve drug solubility and bioavailability. By exploring these aspects, we can unlock the full potential of solid dispersion technology and develop innovative solutions for poorly soluble drugs.
Jain et al. (2025) studied this question.