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September 30, 2025Immunity Inflammation and Disease0 citationsOpen Access

RETRACTION: PRMT5 Participates in B Cell Overactivation in Patients With Primary Sjogren's Syndrome (pSS) Through RSAD2‐Mediated NF‐κB Signaling

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Key Points

  • Reanalysis of the data has led to the retraction of the findings on the role of prmt5 in B cell overactivation.
  • The study previously reported duplicated western blot bands, affecting key results concerning nf-kb signaling.
  • Concerns arose from an unexpected male participant ratio and vague funding disclosures, weakening the study's credibility.
  • Lack of communication from authors on serious allegations leaves trust in the research outcomes significantly diminished.

Abstract

RETRACTION: H. Zhu, J. Zheng, Y. Zhou, T. Wu, and T. Zhu, “PRMT5 Participates in B Cell Overactivation in Patients With Primary Sjogren's Syndrome (pSS) Through RSAD2‐Mediated NF‐κB Signaling,” Immunity, Inflammation and Disease 11, no. 12 (2023): e1102, https://doi.org/10.1002/iid3.1102 . The above article, published online on 13 December 2023 in Wiley Online Library ( wileyonlinelibrary.com ), has been retracted by agreement between the authors; the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons, Ltd. The retraction has been agreed upon due to the identification of duplication of the p‐p65 western blot bands between Figures 4C and 6E. The duplication consists of rotated versions of the same bands, which were used to represent different scientific conditions. Discrepancies were also noted in the participant profile and funding information. The study included an unusually high proportion of male participants for a condition known to predominantly affect women. Additionally, the funding statement lacked institutional attribution and appeared misaligned with the study's focus. The authors did not respond to invitations to comment on the concerns or provide supporting data. As a result, the editors consider the results and conclusions to be compromised.

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Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68db4105b4a4d9ad2f982ef8https://doi.org/10.1002/iid3.70269
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