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June 1, 2024Annals of the Rheumatic Diseases

Op0128 Spatial Transcriptomics Implicates Glandular Cell Involvement in Pathophysiology of Sjögren’s Disease

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Authors

SYShun YaoRWR. WilbrinkPCP. Czarnota

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Overview

Observational analysis demonstrates distinct tissue cluster dysregulation in Sjögren's disease salivary glands, highlighting antibody-specific pathway differences.

Key Points

  • Spatial transcriptomics profiling revealed widespread pathway dysregulation across salivary gland tissue clusters in Sjögren's disease.
  • Across 34,948 tiles from 41 subjects, interferon gamma emerged as the top dysregulated pathway in Ro-positive patients across 8 clusters.
  • Assessment using HistoSpatialPCA dimensional reduction clustered heterogeneous minor salivary gland tiles after 10X Visium capture sequencing.
  • Highlights cellular heterogeneity in Sjögren's disease pathobiology and supports spatially aware profiling to identify tissue specific targets.

Cite This Study

Yao et al. (2024) studied this question.

synapsesocial.com/papers/68e6706cb6db6435875fb36fhttps://doi.org/10.1136/annrheumdis-2024-eular.1518
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