Mean arterial pressure was not associated with an increased risk of developing type 2 diabetes mellitus in Japan, with HR 1.10 (0.75, 1.61), p = 0.6363.
Does elevated mean arterial pressure (MAP) increase the risk of incident type 2 diabetes mellitus in a Japanese population?
Elevated mean arterial pressure is not an independent risk factor for the development of type 2 diabetes in the Japanese population after adjusting for metabolic and lifestyle confounders.
The association between mean arterial pressure (MAP) and diabetes has been explored in some studies; however, the results have been controversial. This longitudinal cohort study included 8,430 males and 7,034 females. The follow-up period lasted for 13 years, from 1994 to 2016. We categorized the participants according to the MAP quartiles. We investigated the association between MAP and type 2 diabetes mellitus (T2DM) and expressed it as hazard ratios (HRs) with 95% confidence intervals (CIs) after adjusting for potential confounders. After multivariate adjustment, we found that MAP was not a risk factor for incident T2DM using Cox regression analysis. The HR at the highest quartile of MAP was 1.10 (0.75, 1.61), p = 0.6363, compared to the lowest quartile of MAP. In the subgroup analysis, there was no interaction between MAP and the development of T2DM. MAP was not associated with the incidence of T2DM in Japan. Not applicable.
Zheng et al. (2026) studied this question. Mean arterial pressure was not associated with an increased risk of developing type 2 diabetes mellitus in Japan, with HR 1.10 (0.75, 1.61), p = 0.6363.