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January 14, 2026Open Forum Infectious DiseasesOpen Access

P-560. The Genomic Epidemiology of Fulminant Streptococcus pyogenes Infections in Rochester, NY: Why Community Surveillance Matters

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Authors

VFVishal FnuFLFrançois LebretonTLTing Luo

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Overview

Observational study evaluates genomic relatedness of fulminant infections in healthcare workers, suggesting community surveillance is crucial.

Key Points

  • To investigate the genetic relatedness of fulminant Streptococcus pyogenes infections among patients and healthcare workers.
  • Contact tracing and testing of healthcare workers with close patient contact were conducted.
  • Whole genome sequencing was performed on isolated bacteria.
  • Medical records were reviewed retrospectively and prospectively.
  • Genetic relatedness was assessed among collected isolates.
  • 40 isolates from 36 patients and one positive healthcare worker were collected and clustered into 13 lineages.
  • Isolates showed no temporal or epidemiologic connections, despite being related genetically.
  • The index isolate was identified as ST-15 emm 3.1, with virulence genes correlating to strain types.

Cite This Study

Fnu et al. (2026) studied this question.

synapsesocial.com/papers/6966f2f013bf7a6f02c0053ahttps://doi.org/10.1093/ofid/ofaf695.775
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