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February 2, 2026Chemical Science0 citationsOpen Access

From Two to One: Resolving CO Binding in Acetyl-CoA Synthase

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DPD.J. Le PoireCBCornelius Constantin Maria BernitzkyMVMathesh Vaithiyanathan

Key Points

  • This research investigates the binding dynamics of carbon monoxide in acetyl-CoA synthase.
  • Conducted low-temperature ENDOR studies to analyze CO binding
  • Investigated the catalytic process of acetyl-CoA formation
  • Monitored interaction between substrates and the enzyme
  • Identified key interactions between carbon monoxide and acetyl-CoA synthase
  • Demonstrated resolved binding pathways for CO
  • Highlighted implications for the understanding of biomolecular fixation processes

Abstract

Acetyl-CoA synthase (ACS) catalyzes the condensation of acetyl-CoA from carbon monoxide (CO), a methyl group, and coenzyme A, enabling the fixation of CO into biomolecules. Recent low-temperature ENDOR studies proposed...

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Cite This Study

Poire et al. (2026) studied this question.

synapsesocial.com/papers/6980fbbec1c9540dea80d7f5https://doi.org/10.1039/d5sc08875e
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From two to one: resolving CO binding in acetyl-CoA synthase2026
  2. 2From two to one: resolving CO binding in acetyl-CoA synthase2026
  3. 3Snapshots of acetyl-CoA synthesis, the final step of CO<sub>2</sub>fixation in the Wood-Ljungdahl pathway2024
  4. 4Coupling CO2 Reduction and Acetyl‐CoA Formation: The Role of a CO Capturing Tunnel in Enzymatic Catalysis2024 · 6 citations
  5. 5Mechanistic Aspects of Thioester Formation by Binuclear Nickel(II)-thiolate as a Functional Model of the Ni <sub>p</sub> Site of Acetyl-CoA Synthase2026