What question did this study set out to answer?

The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.

February 9, 2026

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.
Examined the effects of mTOR deletion on CD4+ T cells
Studied the role of autophagosome-lysosome fusion
Analyzed endpoints related to endoplasmic reticulum stress (ERS) and apoptosis
mTOR deletion significantly alleviated ERS-induced apoptosis in CD4+ T cells
Increased autophagic flux was noted following mTOR deletion
The mTOR-autophagy-ERS-apoptosis axis was established as a novel pathway in sepsis

Abstract

we proved that mTOR deletion could alleviate CD4 + T cells ERS-apoptosis by rescuing autophagy involving autophagosome -lysosome fusion. For the first time, we demonstrate the mTOR-autophagy-ERS-apoptosis axis in sepsis, enriching the targets for future discovery of new sepsis therapies.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Xianli Lei

Guoyu Zhao

Yawen Xie

Actions

Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Beijing Chao-Yang Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider