mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.

Key Points

• The study aims to explore how mTOR affects the apoptosis of CD4+ T cells through autophagy during sepsis.
• Examined the effects of mTOR deletion on CD4+ T cells
• Studied the role of autophagosome-lysosome fusion
• Analyzed endpoints related to endoplasmic reticulum stress (ERS) and apoptosis
• mTOR deletion significantly alleviated ERS-induced apoptosis in CD4+ T cells
• Increased autophagic flux was noted following mTOR deletion
• The mTOR-autophagy-ERS-apoptosis axis was established as a novel pathway in sepsis

Abstract