PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 26, 2026Substance Use &amp Addiction Journal1 citations

When Agitation Meets Intoxication: A Retrospective Comparison of Intramuscular Olanzapine and Haloperidol Among Patients With and Without Substance Use in a Psychiatric Emergency Service

View Full Paper
SLSean T. LynchCEChelsea EisenachMMMichael T. Mangold

Key Points

  • To compare the effectiveness and safety of intramuscular olanzapine and haloperidol for treating agitation in patients with and without substance use.
  • Retrospective analysis of patient records
  • Comparison of response to IM olanzapine and haloperidol
  • Assessment of safety concerns related to treatments
  • Patients with substance use showed similar or greater responses to both medications
  • No increase in safety concerns was observed in patients with substance use
  • Findings suggest implications for treating agitation in high-risk populations

Abstract

Patients with active substance use exhibited similar or greater responses to standard IM treatment for agitation without increased safety concerns. Findings support potential safety and efficacy of common pharmacologic approaches in this high-risk population, though a modest single-site cohort may limit generalizability. There is a need for prospective, multisite replication.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Lynch et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd5afdc3bde448919972https://doi.org/10.1177/29767342261427167
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alcohol, Tobacco, and Nonmedical Drug Use in Older U.S. Adults: Data from the 2001/02 National Epidemiologic Survey of Alcohol and Related Conditions2009 · 147 citations
  2. 2Substance use in psychiatric crisis: relationship to violence2020 · 15 citations
  3. 3Increasing Emergency Department Visits for Mental Health Conditions in the United States2020 · 125 citations
  4. 4Racial/Ethnic Differences in Adolescent Substance Use: Mediation by Individual, Family, and School Factors2010 · 134 citations
  5. 5The Brøset violence checklist (BVC)2002 · 162 citations