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January 29, 2019JAMA718 citationsOpen Access

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

BFBrian A. FerenceJKJohn J.P. KasteleinKRKausik K. Ray

Key Points

  • To explore the relationship between triglyceride-lowering LPL variants, LDL-C-lowering LDLR variants, and the risk of coronary heart disease (CHD).
  • Analyzed LPL and LDLR gene variants related to triglyceride and LDL-C levels.

Structured PICO

Do triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants reduce the risk of coronary heart disease?

I
Intervention
Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants
O
Outcome
Risk of Coronary Heart Disease (CHD)hard clinical

The clinical benefit of lowering triglyceride and LDL-C levels appears to be proportional to the absolute change in ApoB.

Abstract

Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants were associated with similar lower risk of CHD per unit difference in ApoB. Therefore, the clinical benefit of lowering triglyceride and LDL-C levels may be proportional to the absolute change in ApoB.

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Cite This Study

Ference et al. (2019) studied this question.

synapsesocial.com/papers/69cdfe8c3d84e1f5ff46c483https://doi.org/10.1001/jama.2018.20045
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