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April 5, 2026Cancer Research

Abstract 2107: Genomic landscape of melanoma brain metastases: Real-world analysis and comparison with public melanoma cohorts.

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Authors

DEDina ElantablyJPJoseph B. ParkerJHJakob Hamilton

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Overview

Real-world analysis reveals distinct genomic features of melanoma brain metastases, suggesting unique biological characteristics.

Key Points

  • This research aims to define the genomic landscape of melanoma brain metastases and compare these findings to public melanoma datasets.
  • Retrospective identification of 166 patients with confirmed melanoma brain metastases.
  • Molecular testing conducted on 123 patients, utilizing various next-generation sequencing platforms.
  • Comparison of genomic alterations against existing melanoma datasets from TCGA and MSK.
  • Assessment of tumor-suppressor and MAPK pathway alterations based on comprehensive profiling.
  • BRAF mutations were found in 48.8% of patients, with specific subtypes reported.
  • Alterations in tumor-suppressor genes such as CDKN2A (17.5%) and TERT promoter mutations (22.9%) were significant findings.
  • Median tumor mutational burden was 11.55 mut/Mb, indicating a diverse genomic landscape.
  • Melanoma brain metastases exhibited fewer MAPK and tumor-suppressor co-alterations compared to public cohorts.

Cite This Study

Elantably et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd4ea79560c99a0a34fahttps://doi.org/10.1158/1538-7445.am2026-2107
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