Does a signature of four circulating miRNAs distinguish Takotsubo cardiomyopathy from STEMI?
A novel signature of four circulating miRNAs can robustly differentiate Takotsubo cardiomyopathy from STEMI, providing a potential new diagnostic biomarker and supporting a microvascular spasm pathophysiological link.
The present study for the first time describes a signature of four circulating miRNAs as a robust biomarker to distinguish TTC from STEMI patients. The significant up-regulation of these stress- and depression-related miRNAs suggests a close connection of TTC with neuropsychiatric disorders. Moreover, decreased levels of miRNA125a-5p as well as increased plasma levels of its target ET-1 are in line with the microvascular spasm hypothesis of the TTC pathomechanism.
Jaguszewski et al. (2013) studied this question.
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