A persistent craniopharyngeal canal harboring adenohypophyseal lineages associated with Rathke’s cleft cyst: illustrative case

Key Points

• The aim is to highlight the persistence of pituitary tissue in craniopharyngeal canals and its lineages.
• Imaging techniques to identify type 1 craniopharyngeal canal (CPC) features.
• Analysis of adenohypophyseal cell remnants within the canal.
• Characterization of transcription factor profiles related to lineage specificity.
• Identification of residual adenohypophyseal cells within the CPC.
• Multiple lineage-specific transcription factor profiles observed in these cells.
• Evidence supporting developmental arrest of Rathke's pouch remnants.

Abstract