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September 3, 2021Cellular & Molecular Biology Letters213 citationsOpen Access

HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

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Population

HUVECs (Human Umbilical Vein Endothelial Cells)

Design

Preclinical

Authors

MZMin ZhaoSWShao‐Ting WangAZAnna Zuo

Discussion

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Overview

No immediate clinical implications in diabetic vasculopathy; leaves open HIF-1α/JMJD1A targeting for mechanistic and translational studies.

Structured PICO

P
Population
HUVECs (Human Umbilical Vein Endothelial Cells)
I
Intervention
High glucose and hypoxia exposure
O
Outcome
Inflammation and oxidative stresssurrogate

The HIF-1α/JMJD1A signaling pathway regulates oxidative stress and inflammation in diabetic vascular injury models, presenting a potential mechanistic target.

Cite This Study

Zhao et al. (2021) studied this question.

synapsesocial.com/papers/69d94a66da3af5b1d08362cfhttps://doi.org/10.1186/s11658-021-00283-8
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