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April 13, 2026Current Molecular PharmacologyOpen Access

PVT1&EIF4A1 promote metastasis through regulating Notch-1 signaling pathway via STC-1 in gastric cancer

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Authors

DCDongdong CaoRYRui YangLZL Zhang

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Overview

This investigation reveals PVT1 and EIF4A1 as drivers of metastasis in gastric cancer, suggesting new therapeutic targets.

Key Points

  • The aim is to understand how PVT1 and EIF4A1 contribute to metastasis in gastric cancer through the Notch-1 signaling pathway.
  • Identified binding site of PVT1 and EIF4A1 using RNA-binding protein immunoprecipitation (RIP).
  • Used 4D-DIA proteomics and mass spectrometry to discover downstream proteins regulated by PVT1 and EIF4A1.
  • Assessed cell proliferation and migration after STC1 knockdown through various assays (MTT, colony formation, wound healing, Transwell).
  • Examined epithelial-mesenchymal transition (EMT) and Notch-1 signaling in gastric cancer cells.
  • PVT1 and EIF4A1 promote the expression of STC1, which correlates with metastasis in gastric cancer.
  • Inhibition of EIF4A1 reduces STC1 levels, indicating its role as a target in the PVT1/EIF4A1 pathway.
  • Knockdown of STC1 leads to decreased gastric cancer cell migration, proliferation, and suppressed EMT and Notch1 signaling.

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69dc88583afacbeac03ea416https://doi.org/10.1016/j.cmp.2026.02.003
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