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April 13, 2026Current Oncology ReportsOpen Access

Harnessing Proteogenomics to Advance Precision Oncology: From Melanoma and Hepatocellular Carcinoma Perspective

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Authors

AOAbolaji Samson OlagunjuABAyoade D. BabalolaSNSarah Eseroghene Najophe

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Overview

This review demonstrates how proteogenomics enhances tumor profiling in melanoma and hepatocellular carcinoma, indicating its potential for personalized treatment.

Key Points

  • This review examines proteogenomics’ role in improving precision oncology and personalized cancer management.
  • Analysis of key analytical platforms such as mass spectrometry-based proteomics and phosphoproteomics.
  • Discussion of next-generation sequencing and integrative computational pipelines.
  • Review of applications of proteogenomics in melanoma and hepatocellular carcinoma.
  • Proteogenomics captures protein-level functional consequences missing in genomics alone.
  • Enhanced identification of clinically actionable biomarkers and treatment resistance mechanisms.
  • Improvement in diagnostic accuracy for tumor classification.

Cite This Study

Olagunju et al. (2026) studied this question.

synapsesocial.com/papers/69dc89183afacbeac03ead58https://doi.org/10.1007/s11912-026-01764-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteomics-driven precision oncology: from molecular profiling to biomarker discovery2026
  2. 2Proteomics appending a complementary dimension to precision oncotherapy2024 · 7 citations
  3. 3Advancements in the Application of Proteogenomic in Assisting the Discovery of Novel Cancer Antigens2024
  4. 4Integrative proteomics and metabolomics advance early cancer detection and targeted therapy with emerging technologies and clinical applications.2026
  5. 5Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation2024 · 1 citations