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April 16, 2026BMJ Oncology0 citationsOpen Access

CXCR4 in colorectal cancer: from prognostic marker to immunotherapy guide?

CCChao-Yang ChenOLOscar K. Lee

Key Points

  • The research focuses on understanding the role of cxcr4 in colorectal cancer and its potential as both a prognostic marker and a guide for immunotherapy.
  • Literature review on cxcr4 in colorectal cancer
  • Analysis of cxcr4 expression levels in tumor samples
  • Evaluation of therapeutic implications for immunotherapy
  • Cxcr4 is identified as a significant biomarker associated with poor outcomes in metastatic colorectal cancer.
  • Higher cxcr4 levels correlate with increased tumor aggressiveness and metastasis.
  • Potential strategies involving cxcr4 targeting in immunotherapy are discussed.

Abstract

Colorectal cancer (CRC) remains a major global health burden, and despite advances in systemic therapy, outcomes for metastatic disease remain poor.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69e07c1e2f7e8953b7cbd804https://doi.org/10.1136/bmjonc-2026-001129
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunotherapy in Colorectal Cancer — Finding the Achilles’ Heel2024 · 10 citations
  2. 2Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome2006 · 6,545 citations
  3. 3CXCR4 mRNA overexpression: an indicator of poor survival and predictor of response to immune checkpoint inhibitors in patients with metastatic colorectal cancer2026 · 1 citations
  4. 4Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy2017 · 2,360 citations
  5. 5CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response2020 · 266 citations