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April 16, 2026Breathe0 citationsOpen Access

A case of breathlessness and unexpected antibodies: stating the obvious

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IDIlias E. DimeasGPG PerlepePKP Kirgou

Key Points

  • To investigate the relationship between pravastatin use and the onset of breathlessness and antibodies in a patient.
  • Case report of a patient with breathlessness after starting pravastatin.
  • Assessment of antibodies and interstitial changes was conducted.
  • Statin withdrawal was performed as an intervention to evaluate recovery.
  • The patient showed transient positivity for anti-HMGCR antibodies.
  • Breathlessness improved fully after stopping pravastatin.
  • Findings underscore the need for careful drug causality assessment in interstitial lung disease.

Abstract

Shareable abstract A patient developed breathlessness after starting pravastatin, with transient anti-HMGCR positivity and interstitial changes. Statin withdrawal led to full recovery, highlighting the importance of drug causality assessment in ILD. https://bit.ly/4rdPDZl

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Cite This Study

Dimeas et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe24ehttps://doi.org/10.1183/20734735.0358-2025
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