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April 17, 2026Surgical Case Reports0 citationsOpen Access

Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report

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TYTakahiro YoshimuraHHHironori HayashiKKKazuki Kato

Key Points

  • To highlight the rare synchronous occurrence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the liver.
  • Case report of a patient with synchronous tumors
  • Assessment of tumor locations and characteristics
  • Review of literature on double primary hepatic cancers
  • Identified two distinct tumors in different liver locations
  • Observed that this condition occurs in less than 0.8% of liver malignancies
  • Emphasized the need for further research into DPHC

Abstract

INTRODUCTION: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are the most common and second most common primary liver cancers, respectively. In contrast, double primary hepatic cancer (DPHC), the synchronous occurrence of these two tumors in different locations of the liver, is an uncommon pathology, occurring in less than 0.8% of all liver malignancies.

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Cite This Study

Yoshimura et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce065cdc762e9d85727fhttps://doi.org/10.70352/scrj.cr.25-0720
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A rare case of synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma: A case report2024 · 1 citations
  2. 2A case of synchronous double primary combined hepatocellular-cholangiocarcinoma complicated with gallbladder adenocarcinoma: a rare case report2026
  3. 3Triple primary synchronous liver cancer in one patient: the first case report and origin speculation through bioinformatics2026
  4. 4280 A Fascinating Case of Combined Hepatocellular Carcinoma-Cholangiocarcinoma (cHCC-CCA) diagnosed on Liver Core Biopsy2025
  5. 5Combined hepatocellular-cholangiocarcinoma: a contemporary pathologic and molecular perspective2026 · 1 citations