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April 18, 2026Communications BiologyOpen Access

Spatially and temporally comparative proteomics provide insights into dynamic response patterns to PEDV infection

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Authors

WJWenjiao JinYFYu FengSMSijia Ma

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Overview

Spatiotemporal comparative proteomics reveals dynamic response patterns to PEDV in piglet intestines, suggesting intervention strategies.

Key Points

  • This study aims to characterize host response patterns at the protein level to PEDV infection in pig intestines.
  • Conducted spatiotemporal comparative proteomics analysis on jejunal and colon tissues
  • Quantified cellular proteins during different stages of PEDV infection
  • Integrated multidimensional host proteomics to assess regional responses
  • Identified dynamic remodeling of glucose and lipid metabolism in response to PEDV
  • Revealed regional variability in antiviral responses among different intestinal segments
  • Highlighted the significance of the localized proteome in understanding infection mechanisms

Cite This Study

Jin et al. (2026) studied this question.

synapsesocial.com/papers/69e31f7340886becb653eb49https://doi.org/10.1038/s42003-026-10057-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated Metabolomic and Transcriptomic Analysis Reveals Host Response Mechanisms to Porcine Epidemic Diarrhea Virus Infection in Pigs2026
  2. 2Metabolic reprogramming in the enterocytes of neonatal piglets infected with porcine epidemic diarrhea virus: integrated omics and multi-batch analysis highlight alterations in lipid metabolism and potential therapeutic targets.2026
  3. 3PEDV Structural Proteins with Emphasis on M Protein as an Immunomodulatory Factor in Porcine Innate Immunity2025
  4. 4Impact of PEDV infection on the biological characteristics of porcine intestinal exosomes2024 · 2 citations
  5. 5An isotonic protein solution favorably modulated the porcine intestinal immune response and cellular adhesion markers and reduced PEDV shedding in vivo2024 · 2 citations