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April 22, 2026MedicinaOpen Access

Effects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber Film on Postoperative Pain and Peritoneal Adhesion in a Rat Model

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Authors

HKHa-Young KimHKHyo-jin KimGCGeun Joo Choi

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Overview

This investigation reveals lidocaine-loaded film reduces postoperative pain and adhesions in rats, suggesting effective dual therapy.

Key Points

  • To evaluate the efficacy of a lidocaine-loaded alginate, CMC, and PEO electrospun film for reducing postoperative pain and adhesions.
  • Comparison of saline control, free lidocaine, drug-free ACPE film, and lidocaine-loaded ACPE film across four groups of rats.
  • Assessment of mechanical withdrawal threshold after incision, along with histological evaluation of adhesions and inflammation.
  • Use of the Moreno system to score adhesions.
  • Lidocaine-loaded ACPE film significantly improved mechanical withdrawal threshold versus all other treatments.
  • Lower adhesion scores were observed in the lidocaine film group, indicating reduced adhesion formation.
  • Histological analysis showed decreased inflammatory cell infiltration and collagen deposition in the film-treated group.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69e866616e0dea528ddeabb1https://doi.org/10.3390/medicina62040789
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