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May 6, 2026FEBS LettersOpen Access

pH ‐mediated activation of the lysosomal arginine sensor SLC38A9

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Authors

XMXuelang MuAHAmpon Sae HerTGTamir Gonen

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Overview

Investigating pH effects on amino acid transport in lysosomes reveals insights into mTORC1 signaling.

Key Points

  • This research explores the pH regulation of the lysosomal arginine sensor SLC38A9.
  • Investigated how pH influences SLC38A9 activity and arginine uptake.
  • Examined the role of His544 as a pH sensor in SLC38A9.
  • Compared the structures of SLC38A9 at different pH levels to understand its activation.
  • Arginine uptake is demonstrated to be pH-dependent.
  • Mutation of His544 removes the pH dependence without affecting overall transport.
  • Demonstrated a model for pH-induced activation of SLC38A9 influencing mTORC1 signaling.

Cite This Study

Mu et al. (2026) studied this question.

synapsesocial.com/papers/69fa97ce04f884e66b5319e9https://doi.org/10.1002/1873-3468.70352
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