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May 6, 2026Circulation

Abstract WE514: Changes in epigenomics and metabolomics biomarkers after a lifestyle intervention with diet and physical activity for weight loss in high cardiovascular risk individuals

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Authors

ÓCÓscar ColtellRCRebeca Fernández CarriónJSJosé Sorlí

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Overview

Randomized controlled trial reveals significant weight loss and epigenomic changes in obesity with Mediterranean diet and exercise.

Key Points

  • To analyze the impact of a lifestyle intervention on epigenomics and metabolomics biomarkers for weight loss in high cardiovascular risk individuals.
  • Conducted a randomized controlled trial with overweight/obese subjects at high cardiovascular risk.
  • Intervention group followed an energy-restricted Mediterranean diet and increased physical activity.
  • DNA methylation and metabolites measured using EPIC array and NMR-Nightingale platform.
  • Analyzed changes over one year, focusing on responders and non-responders.
  • Intervention group had a mean weight loss of 3.4% compared to 0.42% in control group (P<0.001).
  • Significant associations found between DNA methylation changes and weight loss.
  • Identified changes in metabolites after intervention, indicating the impact of lifestyle on biomarkers.

Cite This Study

Coltell et al. (2026) studied this question.

synapsesocial.com/papers/69faa22704f884e66b532e46https://doi.org/10.1161/cir.153.suppl_1.we514
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