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May 8, 2026Open Access

Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK

Key Points

This research aims to evaluate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an ICU setting.
Conducted whole-genome sequencing on samples from ICU patients in the UK.
Implemented prospective screening for multidrug-resistant Gram-negative bacteria.
Analyzed infection transmission patterns and control measures.
Screening identified significant prevalence of multidrug-resistant Gram-negative pathogens.
Early detection led to prompt infection control interventions.
Increased awareness of transmission dynamics improved overall infection management.

Abstract

Our findings suggest that prospective screening for MDR GNB in ICU patients could be beneficial and be considered in other UK critical care settings. This would not only improve early detection but also enable the prompt institution of enhanced infection control measures.

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Authors

Hayley Wilson

Petra Polgarova

Fahad Khokhar

Journals

Microbial Genomics

Actions

Institutions

University of Cambridge

Wellcome Sanger Institute

Cambridge University Hospitals NHS Foundation Trust

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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