Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK

Key Points

• This research aims to evaluate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an ICU setting.
• Conducted whole-genome sequencing on samples from ICU patients in the UK.
• Implemented prospective screening for multidrug-resistant Gram-negative bacteria.
• Analyzed infection transmission patterns and control measures.
• Screening identified significant prevalence of multidrug-resistant Gram-negative pathogens.
• Early detection led to prompt infection control interventions.
• Increased awareness of transmission dynamics improved overall infection management.

Abstract